Obstetrics & Gynecology Email Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Obstetrics & Gynecology 2000;96:45-49
© 2000 by The American College of Obstetricians and Gynecologists
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KUPFERMINC, M. J.
Right arrow Articles by LESSING, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KUPFERMINC, M. J.
Right arrow Articles by LESSING, J. B.

ORIGINAL RESEARCH

Severe Preeclampsia and High Frequency of Genetic Thrombophilic Mutations

M. J. KUPFERMINC, MD, G. FAIT, MD, A. MANY, MD, D. GORDON, MD, A. ELDOR, MD and J. B. LESSING, MD

From the Department of Obstetrics and Gynecology, Lis Maternity Hospital, and the Department of Hematology, Tel-Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Address reprint requests to: M. J. Kupferminc, MD, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239 Israel, E-mail: tmcobgyn{at}tasmc.health.gov.il

Objective: To determine whether severe preeclampsia is associated with genetic thrombophilic mutations or other types of thrombophilia.

Methods: A case-control study compared 63 consecutive women with severe preeclampsia evaluated at our institution between November 1997 and April 1999 with 126 control women matched for age and ethnicity. All of these women were tested several months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase, and prothrombin gene; for deficiencies of protein C, protein S, and antithrombin-III; and for the presence of anticardiolipin antibodies.

Results: Thirty-five study women (56%) had a thrombophilic mutation compared with 24 control women (19%), P < .001. Seven other study women (11%) had other thrombophilias, compared with one control woman (0.8%), P < .01. Within the study group, women with thrombophilia delivered at an earlier gestational age, and their neonates’ birth weights were lower compared with those of women without thrombophilia.

Conclusion: Because thrombophilia was found in 67% of women with severe preeclampsia, we suggest that women who have severe preeclampsia should be tested for thrombophilia.




This article has been cited by other articles:


Home page
 Therapeutic Advances in Cardiovascular DiseaseHome page
I. Craici, S. Wagner, and V. D. Garovic
Review: Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Therapeutic Advances in Cardiovascular Disease, August 1, 2008; 2(4): 249 - 259.
[Abstract] [PDF]

Home page
 Obstet GynecolHome page
S. Okazaki, A. Sekizawa, Y. Purwosunu, A. Farina, N. Wibowo, and T. Okai
Placenta-Derived, Cellular Messenger RNA Expression in the Maternal Blood of Preeclamptic Women
Obstet. Gynecol., November 1, 2007; 110(5): 1130 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. Mello, E. Parretti, L. Marozio, C. Pizzi, A. Lojacono, T. Frusca, F. Facchinetti, and C. Benedetto
Thrombophilia Is Significantly Associated With Severe Preeclampsia: Results of a Large-Scale, Case-Controlled Study
Hypertension, December 1, 2005; 46(6): 1270 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
J. Lin and P. August
Genetic Thrombophilias and Preeclampsia: A Meta-Analysis
Obstet. Gynecol., January 1, 2005; 105(1): 182 - 192.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. Mello, E. Parretti, C. Fatini, C. Riviello, F. Gensini, M. Marchionni, G. F. Scarselli, G. F. Gensini, and R. Abbate
Low-Molecular-Weight Heparin Lowers the Recurrence Rate of Preeclampsia and Restores the Physiological Vascular Changes in Angiotensin-Converting Enzyme DD Women
Hypertension, January 1, 2005; 45(1): 86 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
J. Laasanen, M. Hiltunen, K. Punnonen, A. Mannermaa, and S. Heinonen
Fibrinogen and Factor VII Promoter Polymorphisms in Women With Preeclampsia
Obstet. Gynecol., August 1, 2002; 100(2): 317 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
D. Prasmusinto, S. Skrablin, C. Hofstaetter, R. Fimmers, and K. van der Ven
The Methylenetetrahydrofolate Reductase 677 C->T Polymorphism and Preeclampsia in Two Populations
Obstet. Gynecol., June 1, 2002; 99(6): 1085 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
A. Many, R. Elad, Y. Yaron, A. Eldor, J. B. Lessing, and M. J. Kupferminc
Third-Trimester Unexplained Intrauterine Fetal Death Is Associated With Inherited Thrombophilia
Obstet. Gynecol., May 1, 2002; 99(5): 684 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
C. J. Lockwood
Inherited Thrombophilias in Pregnant Patients: Detection and Treatment Paradigm
Obstet. Gynecol., February 1, 2002; 99(2): 333 - 341.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
K. M O'Shaughnessy, B. Fu, S. Downing, and N. H Morris
Thrombophilic polymorphisms in pre-eclampsia: altered frequency of the functional 98C>T polymorphism of glycoprotein IIIa
J. Med. Genet., November 1, 2001; 38(11): 775 - 777.
[Full Text] [PDF]

Home page
 Obstet GynecolHome page
Z. ALFIREVIC, H. A. MOUSA, V. MARTLEW, L. BRISCOE, M. PEREZ-CASAL, and C. H. TOH
Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications
Obstet. Gynecol., May 1, 2001; 97(5): 753 - 759.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American College of Obstetricians and Gynecologists.