HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MCDERMOTT, S. Articles by DAGUISE, V. Search for Related Content PubMed PubMed Citation Articles by MCDERMOTT, S. Articles by DAGUISE, V.

Urinary Tract Infections During Pregnancy and Mental Retardation and Developmental Delay

From the Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, and the South Carolina Budget and Control Board, Office of Research and Statistics, Columbia, South Carolina.

Address reprint requests to: Suzanne McDermott, PhD, University of South Carolina School of Medicine, Family Practice Center, 6 Richland Medical Park, Columbia, SC 29203, E-mail: scmdermott{at}rmh.edu

Objective: To investigate the association between urinary tract infections during pregnancy and mental retardation or developmental delay in infants.

Methods: An inception cohort design was used to analyze Medicaid maternal and infant-linked records and vital records for 41,090 pregnancies from 1995–1998.

Results: The relative risk (RR) for mental retardation or developmental delay among infants of mothers with diagnosed urinary tract infections but no antibiotic claims was 1.31 with a 95% confidence interval (CI) of 1.12, 1.54 compared with the group without urinary tract infections. The RR for infants of mothers with urinary tract infections without antibiotic claims was 1.22 (95% CI 1.02, 1.46) compared with infants of mothers with urinary tract infections and antibiotic claims. The RR was significant in the first trimester (1.46, 95% CI 1.07, 1.99) and third trimester (1.41, 95% CI 1.11, 1.79) after controlling for race and gestational age at birth.

Conclusion: There was a statistically significant association between maternal urinary tract infections without evidence of antibiotics and mental retardation or developmental delay in infants. The relationship persisted when we assumed that over 30% of women who had antibiotic claims filled but did not take the medicine, and 40% of the women who did not have antibiotic claims did take the medication.

This article has been cited by other articles:

				Y. Sun, M. Vestergaard, J. Christensen, A. J. Nahmias, and J. Olsen Prenatal Exposure to Maternal Infections and Epilepsy in Childhood: A Population-Based Cohort Study Pediatrics, May 1, 2008; 121(5): e1100 - e1107. [Abstract] [Full Text] [PDF]