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Obstetrics & Gynecology 2000;95:128-133
© 2000 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Malignant Germ Cell Tumors of the Ovary

KRISHNANSU TEWARI, MD, FABIO CAPPUCCINI, MD, PHILIP J. DISAIA, MD, MICHAEL L. BERMAN, MD, ALBERTO MANETTA, MD and MATTHEW F. KOHLER, MD

From the Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of California, Irvine—Medical Center, Orange, California.

Address reprint requests to: Matthew F. Kohler, MD, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-2233 E-mail: kohlermf{at}musc.edu

Objective: To evaluate the efficacy of adjuvant therapy for ovarian germ cell tumors.

Methods: We reviewed records of women who had malignant germ cell tumors of the ovary from 1977–1997.

Results: Seventy-two women had surgical resections of malignant ovarian germ cell tumors and most received adjuvant therapy. Fifty-six women (78%) presented with stage I disease, and 16 (22%) had more advanced disease. Tumor subtypes included dysgerminoma (n = 20), yolk sac tumor (n = 8), immature teratoma (n = 29) and mixed germ cell tumor (n = 15). Surgical management of the 56 with stage I disease consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy, and extensive surgical staging in ten women, whereas a conservative surgical approach, consisting of unilateral adnexectomy with or without comprehensive surgical staging, was adopted in later years (n = 46). Fifty-six women were treated with postoperative chemotherapy, predominantly platinum-based regimens. The 5-year actuarial survival rate was 93%. None of the 36 women who presented after 1984 have died of disease.

Conclusion: These data confirmed that platinum-based adjuvant treatments allow most women with ovarian germ cell malignancies to have conservative surgery without compromising survival.




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 Obstet GynecolHome page
H. O. Smith, M. Berwick, C. F. Verschraegen, C. Wiggins, L. Lansing, C. Y. Muller, and C. R. Qualls
Incidence and Survival Rates for Female Malignant Germ Cell Tumors.
Obstet. Gynecol., May 1, 2006; 107(5): 1075 - 1085.
[Abstract] [Full Text] [PDF]


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