HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cullimore, A. J. Articles by Brennan, B. G. Search for Related Content PubMed PubMed Citation Articles by Cullimore, A. J. Articles by Brennan, B. G.

PREGNANCY IN WOMEN WITH NOONAN SYNDROME: REPORT OF TWO CASES

From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology and the Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada.

Address reprint requests to: Barbara G. Brennan, MD, PhD Department of Obstetrics and Gynecology McMaster University 1200 Main Street West, Room HSC-4F8 Hamilton, ON L8N 3Z5 Canada E-mail: brennanb{at}fhs.mcmaster.ca

Background: Noonan syndrome is similar phenotypically to Turner syndrome, accounting for one in 1000–2500 live births. Two thirds of patients have cardiac anomalies, half with pulmonary stenosis. Two cases of Noonan syndrome in pregnancy are presented, each woman with a different cardiac anomaly.

Cases: The first patient sought preconception counseling for pulmonary stenosis. She conceived within a year and had a cesarean because of prolonged rupture of membranes, transverse lie, and variable decelerations. The second patient presented at 14 weeks’ gestation with an unrepaired coarctation of the aorta. She had an assisted vaginal delivery at 38 weeks.

Conclusion: Successful pregnancy was possible in women with Noonan syndrome. A coordinated multidisciplinary team approach improved the likelihood of a successful outcome.