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Obstetrics & Gynecology 1999;93:571-575
© 1999 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

A Comparison of Two Dosing Regimens of Intravaginal Misoprostol for Second-Trimester Pregnancy Termination

JOHN K. JAIN, MD, JOHN KUO and DANIEL R. MISHELL, Jr, MD

From the Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Women’s & Children’s Hospital, Los Angeles County Medical Center–University of Southern California, Los Angeles, California.

Address reprint requests to: John K. Jain, MD, Department of Obstetrics and Gynecology, Women’s & Children’s Hospital, 1240 North Mission Road, Room 8K6, Los Angeles, CA 90033, E-mail: sdavenpo{at}hsc.usc.edu

Objective: To compare the effectiveness of misoprostol administered intravaginally every 6 versus every 12 hours for termination of second-trimester pregnancies.

Methods: One hundred pregnant women at 12–22 weeks’ gestation were randomized to receive 200 µg of misoprostol intravaginally either every 6 or every 12 hours for up to 48 hours.

Results: The incidences of abortion within 48 hours after initial drug administration were 87.2 and 89.2%, the complete abortion rates 43.9 and 33.3%, and the mean abortion intervals 13.8 and 14.0 hours in the 6- and 12-hour groups, respectively. Side effects were similar between groups.

Conclusion: Misoprostol administered vaginally is effective for terminating second-trimester pregnancies. Shortening the dosing interval from 12 to 6 hours produced no significant benefit.




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