| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
OBJECTIVE: To determine whether results of second-trimester maternal serum triple-marker screening for Down syndrome and open neural tube defects in singleton pregnancies conceived from in vitro fertilization (IVF) differ from those of pregnancies conceived spontaneously. METHODS: The screen-positive rates and triple-marker levels of patients conceiving singleton pregnancies by IVF were compared to age-adjusted standards. RESULTS: Sixty-nine singleton IVF pregnancies with maternal serum screening were identified. Twenty-one (30.4%) of the 69 IVF singleton pregnancies had a positive screen for Down syndrome compared with a 14.4% expected screen-positive rate for the maternal age distribution in our observed sample (P = .013). The screen-positive rate for open neural tube defects in the measured population was similar to anticipated values based on historic controls (5.8% in IVF patients versus 5.3% in the total population). The median levels of the triple markers were 0.95 multiples of the median (MoM) for alpha-fetoprotein (AFP), 0.90 MoM for unconjugated estriol (E3), and 1.22 MoM for hCG. CONCLUSION: The increased hCG levels as well as the slightly lower AFP and unconjugated E3 levels may contribute to the higher Down syndrome screen-positive rate in this IVF singleton population. These results may be due to the number of embryos transferred, the maternal hormonal environment of the IVF process, or other factors. Pregnancies conceived by IVF may be twice as likely to have a positive maternal serum screening test. As additional data are collected, corrected standards should be determined.
This article has been cited by other articles:
|
|
 |
|
  A.C. Gjerris, A. Loft, A. Pinborg, M. Christiansen, and A. Tabor Prenatal testing among women pregnant after assisted reproductive techniques in Denmark 1995-2000: a national cohort study Hum. Reprod., July 1, 2008; 23(7): 1545 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Weisz and C. H. Rodeck An update on antenatal screening for Down's syndrome and specific implications for assisted reproduction pregnancies Hum. Reprod. Update, September 1, 2006; 12(5): 513 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Pan, I. Peter, G. M. Lambert-Messerlian, J. A. Canick, D. W. Bianchi, and K. L. Johnson Cell-free fetal DNA levels in pregnancies conceived by IVF Hum. Reprod., November 1, 2005; 20(11): 3152 - 3156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bellver, C. Lara, S. R. Soares, A. Ramirez, A. Pellicer, J. Remohi, and V. Serra First trimester biochemical screening for Down's syndrome in singleton pregnancies conceived by assisted reproduction Hum. Reprod., September 1, 2005; 20(9): 2623 - 2627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Maslovitz, Y. Yaron, G. Fait, I. Gull, I. Wolman, A. Jaffa, and J. Hartoov Feasibility of Nuchal Translucency in Triplet Pregnancies J. Ultrasound Med., April 1, 2004; 23(4): 501 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.W. Hui, M.H.Y. Tang, Y.H. Lam, E.H.Y. Ng, W.S.B. Yeung, and P.C. Ho Maternal serum hCG and alpha-fetoprotein levels in pregnancies conceived after IVF or ICSI with fresh and frozen-thawed embryos Hum. Reprod., March 1, 2003; 18(3): 572 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maymon and A. Shulman Serial first- and second-trimester Down's syndrome screening tests among IVF-versus naturally-conceived singletons Hum. Reprod., April 1, 2002; 17(4): 1081 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Perheentupa, A. Ruokonen, L. Tuomivaara, M. Ryynanen, and H. Martikainen Maternal serum {beta}-HCG and {alpha}-fetoprotein concentrations in singleton pregnancies following assisted reproduction Hum. Reprod., March 1, 2002; 17(3): 794 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Raty, A. Virtanen, P. Koskinen, L. Anttila, J. Forsstrom, P. Laitinen, P. Morsky, A. Tiitinen, and U. Ekblad Serum free {beta}-HCG and alpha-fetoprotein levels in IVF, ICSI and frozen embryo transfer pregnancies in maternal mid-trimester serum screening for Down's syndrome Hum. Reprod., February 1, 2002; 17(2): 481 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.W. Liao, V. Heath, N. Kametas, K. Spencer, and K.H. Nicolaides First-trimester screening for trisomy 21 in singleton pregnancies achieved by assisted reproduction Hum. Reprod., July 1, 2001; 16(7): 1501 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maymon and A. Shulman Comparison of triple serum screening and pregnancy outcome in oocyte donation versus IVF pregnancies Hum. Reprod., April 1, 2001; 16(4): 691 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maymon, E. Dreazen, Y. Tovbin, I. Bukovsky, Z. Weinraub, and A. Herman The feasibility of nuchal translucency measurement in higher order multiple gestations achieved by assisted reproduction Hum. Reprod., August 1, 1999; 14(8): 2102 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Lam, W. S. B. Yeung, M. H. Y. Tang, E. H. Y. Ng, W. W. K. So, and P. C. Ho Maternal serum alpha-fetoprotein and human chorionic gonadotrophin in pregnancies conceived after intracytoplasmic sperm injection and conventional in-vitro fertilization Hum. Reprod., August 1, 1999; 14(8): 2120 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 False-Positive Triple-Marker Serum Screening in IVF Pregnancies Journal Watch Women's Health, August 1, 1997; 1997(801): 12 - 12. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
