Obstetrics & Gynecology Email Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Obstetrics & Gynecology 1997;89:909-912
© 1997 by The American College of Obstetricians and Gynecologists
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sanchez-Ramos, L
Right arrow Articles by Delke, I
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanchez-Ramos, L
Right arrow Articles by Delke, I

Articles

Labor induction with intravaginal misoprostol in term premature rupture of membranes: a randomized study

L Sanchez-Ramos, AH Chen, AM Kaunitz, FL Gaudier, and I Delke

OBJECTIVE: To evaluate the safety and clinical effectiveness of intravaginal misoprostol, a synthetic prostaglandin E1 analogue, for labor induction in gravidas with premature rupture of membranes (PROM) at term. METHODS: One hundred forty-one pregnant women with term PROM were assigned randomly to one of two induction groups: 1) intravaginal misoprostol or 2) intravenous oxytocin by continuous infusion. RESULTS: Seventy subjects were allocated to the misoprostol group and 71 to the oxytocin group. The mean (+/- standard deviation) interval from induction to delivery was significantly shorter in the misoprostol group (416 +/- 276 compared with 539 +/- 372 minutes; P = .04). In 85.7% of patients in the misoprostol group, only one dose was required. Intrapartum complication rates, mode of delivery, and neonatal or maternal adverse event rates were similar in the two treatment groups. Uterine tachysystole occurred more frequently with misoprostol than with oxytocin (28.6% compared with 14.0%; P < .04). CONCLUSION: Intravaginal administration of misoprostol induces labor safely and effectively in patients with PROM at term.


This article has been cited by other articles:


Home page
 Obstet GynecolHome page
M. G. Lin, F. S. Nuthalapaty, A. R. Carver, A. S. Case, and P. S. Ramsey
Misoprostol for Labor Induction in Women With Term Premature Rupture of Membranes: A Meta-Analysis
Obstet. Gynecol., September 1, 2005; 106(3): 593 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
W. E. Frohn, S. Simmons, and S. J. Carlan
Prostaglandin E2 Gel Versus Misoprostol for Cervical Ripening in Patients With Premature Rupture of Membranes After 34 Weeks
Obstet. Gynecol., February 1, 2002; 99(2): 206 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
K. Blanchard, S. Clark, B. Winikoff, G. Gaines, G. Kabani, and C. Shannon
Misoprostol for Women's Health: A Review
Obstet. Gynecol., February 1, 2002; 99(2): 316 - 332.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. B. Goldberg, M. B. Greenberg, and P. D. Darney
Misoprostol and Pregnancy
N. Engl. J. Med., January 4, 2001; 344(1): 38 - 47.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American College of Obstetricians and Gynecologists.