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Obstetrics & Gynecology 1975;45:443-450
© 1975 by The American College of Obstetricians and Gynecologists
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Ovulation Induction

Ovarian Response to Human Gonadotropins and Synthetic Gonadotropin-Releasing Hormone

JUAN ZANARTU, MD, ALFREDO DABANCENS, MD, ROGELlO RODRIGUEZ-BRAVO, MD, FLORENCIA BARSBY, MD and ANDREW V. SCHALLY, MD

From the Center for the Study of Reproductive Biology (CEBRE), Department of Obstetrics and Gynecology, J. J. Aguirre Hospital, University of Chile Medical School, Santiago, Chile and the Department of Medicine, Tulane University School of Medicine and Veterans Administration Hospital, New Orleans, Louisiana

Abstract

Human ovarian responses to FSH- and LH-releasing hormone (FSH/LH-RH) were observed at laparotomy and studied by histologic and histochemical examination of ovarian biopsy specimens. The responses were compared to those induced by human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) singly and together. The subjects were healthy, fertile, young women rendered anovulatory by injections of depome-droxyprogesterone acetate (DM PA) or depochlormadinone acetate (CA). Supplementary studies included measurement of urinary pregnanediol, examination of the cervix and vagina for estrogenic and progestational responses, and endometrial biopsy. Both HMG and HCG induced follicular growth and proliferation of granulosa and theca cells, but neither, when given alone, induced ovulation or corpus luteum formation. When given in conjunction they induced single or multiple ovulations and corpora lutea in 11 of 18 women treated. FSH/LH-RH consistently stimulated follicular development and induced ovulation in 2 of 1G women treated. Preovulatory mature follicles were found in 3 more. FSH/LH-RH may prove to be useful in the treatment of some cases of anovulatory sterility of hypothalamic origin






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Copyright © 1975 by the American College of Obstetricians and Gynecologists.