HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by BIALE, Y. Articles by ADERET, N B. Search for Related Content PubMed PubMed Citation Articles by BIALE, Y. Articles by ADERET, N B.

Congenital Malformations Due to Anticonvulsive Drugs

From the Department of Obstetrics and Gynecology "A", The Soroka Medical Center, Beersheva, Israel

Abstract

A retrospective study of congenital malformations in the offspring of 20 women who received antiepileptic drugs during pregnancy is presented. Of 56 births, 9 children (16%) were horn with malformations. Four children were born dead or died shortly after delivery. Congenital heart disease, cleft lip with or without cleft palate, neural unbe defects, and skeletal abnormalities were the commonest anomalies found. One child had a recognizable pattern of multiple malformations. The increased peritiatal mortality was mainly due to congenital malformations and spontaneous hemorrhage. The teratogenic activity of anticonvulsant drugs is mediated by interference with folic acid' metabolism, and such activity might be influenced by hereditary and environmental factors. Hearing in mind the importance of anticonvulsant therapy in epilepsy, there is certainly need for an investigation of the problem in a larger and more representative birth population than that described.

This article has been cited by other articles:

				C. Chatot, N. Klein, J Piatek, and L. Pierro Successful culture of rat embryos on human serum: use in the detection of teratogens Science, March 28, 1980; 207(4438): 1471 - 1473. [Abstract] [PDF]