HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HART, W. R. Articles by HELWIG, E. B. Search for Related Content PubMed PubMed Citation Articles by HART, W. R. Articles by HELWIG, E. B.

Relation of Lichen Sclerosus et Atrophicus of the Vulva to Development of Carcinoma

From the Gynecologic and Breast Pathology Branch and Dermal Pathology Branch, Armed Forces Institute of Pathology, Washington, D.C.

Abstract

One hundred and seven patients with lichen sclerosus et atrophicus (LS&A) of the vulva were studied to determine the malignant potential of the LS&A. Five patients had coexisting invasive carcinoma of the vulva or perineum with the LS&A, and 1 patient had coexisting intraepithelial vulvar carcinoma on the clitoris. None of these, however, was known to have LS/A prior to the biopsy for carcinoma of the vulva. The high association of carcinoma and LS&A is probably a result of selection of 2 unusual lesions sent for consultation and evaluation. Squamous hyperplasia in the vulva occurred in association with LS&A in 37 (35%) patients, but only G patients had areas of dysplasia coexisting with LS&A. These areas of dysplasia, like the 5 invasive carcinomas, occurred in an area of the vulva where the LS&A was minimal or absent. Follow-up data were obtained on 92 patients with LS&A. Only 1 developed carcinoma of the vulva, which occurred 12 years after identification of the LS&A. When carcinoma arises in the vulva in a patient with vulvar LS&A, it tends to arise in areas of minimal LS&A or isolated areas of relatively normal vulvar skin. This study did not provide evidence of carcinoma arising from LS&A. Five of the 92 patients developed 6 malignant neoplasms in other sites, including carcinoma of the endometrium (3 patients), lung (1 patient), and simultaneous carcinomas of the colon and cervix

This article has been cited by other articles:

				M van Seters, F J W ten Kate, M van Beurden, R H M Verheijen, C J L M Meijer, M P M Burger, and T J M Helmerhorst In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology J. Clin. Pathol., May 1, 2007; 60(5): 504 - 508. [Abstract] [Full Text] [PDF]

				F. B. Stehman and K. Y. Look Carcinoma of the vulva. Obstet. Gynecol., March 1, 2006; 107(3): 719 - 733. [Abstract] [Full Text] [PDF]

				M. Longinotti, Y. M. Schieffer, and R. H. Kaufman Lichen Sclerosus Involving the Vagina Obstet. Gynecol., November 1, 2005; 106(5): 1217 - 1219. [Abstract] [Full Text] [PDF]