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VULVAR CARCINOMA WITH HYPERCALCEMIA

From the Departments of Gynecology and Obstetrics and Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, and the Departments of Cynccology and Obstetrics and Pathology, The Medical College of Wisconsin, Milwaukee, Wisconsin

Abstract

Hypercalcemia associated with nonmetaslatic malignancy has been reported most frequently with lung or kidney tumors, while among gynecologic malignancies, the ovary has been the most common primary site. The pertinent clinicopathologic features of 2 cases of nonmetastatic vulvar carcinoma producing hypercalcemia are described in the present report. Including 3 previously reported cases, the vulva is seen to be the second must common site in the female genital tract for production of this paraendocrine syndrome. The clinician should be aware of the association of hypercalcemia and mental confusion with bulky vulvar tumors, so that surgery will not needlessly be delayed in a futile attempt to correct the hypercalcemia medically.