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CORTICOSTERONE AND ALDOSTERONE LEVELS DURING THE MENSTRUAL CYCLE

From the Division of Reproductive Biology, Department of Obstetrics and Gynecology, UCLA School of Medicine, Harbor General Hospital Campus, Torrance, California

Using specific radioimmunoassays for aldosteronc (Aldo) and corticosterone (CPD B), the serum levels of these 2 mincralocorticoids were measured daily during 2 consecutive cycles in 5 normally menstruating subjects. Two subjects suffered from cyclic edema and premenstrual tension, respectively. In each patient the first cycle served as control, and the subjects received dexamethasone, 0.5 mg, 2 to 4 times daily during the second cycle. Mean scrum CPD E levels were higher in the luteal phase than in the fullicular phase in the control cycle of all subjects. Dexamethasone treatment decreased peripheral CPD B markedly, with levels -1 to 30 times lower. Serum Aldo was significantly higher in the luteal phase of the control cycle than in the follicular phase in 4 of 5 subjects. The 2 subjects with problems of water retention had significantly higher Aldo levels than the normal women studied. Dexamethasone treatment significantly lowered Aldo levels in these 2 subjects, whereas this treatment caused an increase in peripheral Aldo in 2 of the 3 normal subjects.