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ORIGINAL RESEARCH |
From the Departments of Obstetrics and Gynecology, Surgery (Urology), and Physiology, University of Utah School of Medicine, Salt Lake City, Utah; and The Center for Reproductive Medicine, Minneapolis, Minnesota.
Address reprint requests to: Douglas T. Carrell, PhD, University of Utah School of Medicine, Division of Urology, 50 North Medical Drive, Salt Lake City, UT 84132; E-mail: dcarrell{at}mmsscc.utah.edu.
OBJECTIVE: To evaluate sperm chromosome aneuploidy and semen quality in 24 partners of women with unexplained recurrent pregnancy loss and to analyze the data in relation to sperm apoptosis data.
METHODS: Semen quality parameters and sperm chromosome aneuploidy for chromosomes X, Y, 13, 18, and 21 were evaluated in the recurrent pregnancy loss patients, fertile controls, and a control group of men from the general population.
RESULTS: The mean aneuploidy rate in the recurrent pregnancy loss group was 2.77 ± 0.22, significantly higher (P < .005) than in either the general population (1.48 ± 0.12) or in fertile (1.19 ± 0.11) control groups. In the recurrent pregnancy loss patients, the percentage of aneuploid sperm was correlated to the percentage of apoptotic sperm (r = .62, P < .001). Normal morphology was diminished in the patient group, compared with the general population group (P < .01) and the donor group (P < .001).
CONCLUSION: These data indicate that some recurrent pregnancy loss patients have a significant increase of sperm chromosome aneuploidy, apoptosis, and abnormal sperm morphology. This study demonstrates a new possible cause of recurrent pregnancy loss.
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